Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma

作者：Hua Zhu, Hui Zhang, Feng Jin, Mingzhu Fang, Mark Huang, Chung S. Yang, Tong Chen, Liwu Fu, Zui Pan · 发表于：Oncotarget · 年份：2014 · DOI：10.18632/oncotarget.1903 · 被引用次数：141 · 研究领域：Ion Channels and Receptors、Phytochemicals and Antioxidant Activities、Bioactive Compounds and Antitumor Agents

// Hua Zhu 1,2,* , Hui Zhang 4,* , Feng Jin 1 , Mingzhu Fang 5 , Mark Huang 6 , Chung S. Yang 7 , Tong Chen 3 , Liwu Fu 4 , Zui Pan 1 , 3 1 Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH; 2 Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH; 3 Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH; 4 Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China; 5 Environmental and Occupational Health Sciences Institute; 6 Robert Wood Johnson Medical School; 7 Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ; * contribute equally to this work. Correspondence: Zui Pan, email: // Liwu Fu, email: // Keywords : store-operated calcium entry, STIM1, oncogenic, knockdown, xenograft Received : January 31, 2014 Accepted : April 16, 2014 Published : April 17, 2014 Abstract Effective treatment as well as prognostic biomarker for malignant esophageal squamous cell carcinoma (ESCC) is urgently needed. The present study was aimed at identifying oncogenic genes involving dysregulated intracellular Ca 2+ signaling, which is known to function importantly in cellular proliferation and migration. Tumors from patients with ESCC were found to display elevated expression of Orai1, a store-operated Ca 2+...