Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection

作者：Brian R. Murphy, David W. Alling, Mark H. Snyder, Edward E. Walsh, Gregory A. Prince, Robert M. Chanock, V G Hemming, Wm J Rodriguez, H W Kim, Barney S. Graham · 发表于：Journal of Clinical Microbiology · 年份：1986 · DOI：10.1128/jcm.24.5.894-898.1986 · 被引用次数：198 · 研究领域：Respiratory viral infections research、Neonatal Respiratory Health Research、Pneumonia and Respiratory Infections

The serum antibody response of 50 infants and children infected with respiratory syncytial virus (RSV) was determined by a glycoprotein-specific enzyme-linked immunosorbent assay, and the effects of age and preexisting antibody titer at the time of RSV infection on response to the G and F glycoproteins of RSV were examined. The immune response to the G and F glycoproteins was assessed with anti-human immunoglobulin A to permit measurement of the response of young infants in the presence of maternally derived immunoglobulin G. The findings suggested that age primarily affects the response to the F glycoprotein and that preexisting antibody titer affects the response to the G glycoprotein.