Activation of class I major histocompatibility complex gene expression by hepatitis B virus

作者：Dao‐Xiu Zhou, Albert Taraboulos, J.-H. James Ou, T. S. Benedict Yen · 发表于：Journal of Virology · 年份：1990 · DOI：10.1128/jvi.64.8.4025-4028.1990 · 被引用次数：78 · 研究领域：Hepatitis B Virus Studies、Immunotherapy and Immune Responses、Immune Response and Inflammation

Normal hepatocytes express very few class I major histocompatibility complex (MHC I) molecules, but MHC I expression is elevated in hepatitis B virus (HBV) infection. We report here that hepatoblastoma cells with replicating HBV genomes express three- to fourfold-higher levels of MHC I protein and mRNA than do parent cells without HBV DNA. Transient transfection assays demonstrated that the HBV X protein trans activated transcription from an MHC I promoter and allowed identification of cis elements important for trans activation.