Critical role of gap junction communication, calcium and nitric oxide signaling in bystander responses to focal photodynamic injury

作者：Bianca Calì, Stefano Ceolin, Federico Ceriani, Mario Bortolozzi, Andrielly H.R. Agnellini, Veronica Zorzi, Andrea Predonzani, Vincenzo Bronte, Barbara Molon, Fabio Mammano · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.3553 · 被引用次数：32 · 研究领域：Photodynamic Therapy Research Studies、bioluminescence and chemiluminescence research、Effects of Radiation Exposure

// Bianca Calì 1,2 , Stefano Ceolin 3 , Federico Ceriani 1,3 , Mario Bortolozzi 1,3 , Andrielly H.R. Agnellini 1,2 , Veronica Zorzi 1,3 , Andrea Predonzani 4 , Vincenzo Bronte 1,5 , Barbara Molon 4,* and Fabio Mammano 1,3,6,* 1 Foundation for Advanced Biomedical Research, Venetian Institute of Molecular Medicine, Padua, Italy 2 University of Padua, Department of Surgery Oncology and Gastroenterology, Oncology and Immunology Section, Padua, Italy 3 University of Padua, Department of Physics and Astronomy, Padua, Italy 4 IRCCS, Istituto Oncologico Veneto, Padua, Italy 5 Verona University Hospital, Department of Pathology and Diagnostics, Immunology Section, Verona, Italy 6 Present address: CNR, Institute of Cell Biology and Neurobiology, Monterotondo (RM), Italy * These authors contributed equally to this work Correspondence to: Vincenzo Bronte, email: // Barbara Molon, email: // Fabio Mammano, email: // Keywords : cancer, photodynamic therapy, nitric oxide, calcium signaling, connexins Received : January 24, 2015 Accepted : February 14, 2015 Published : March 12, 2015 Abstract Ionizing and nonionizing radiation affect not only directly targeted cells but also surrounding “bystander” cells. The underlying mechanisms and therapeutic role of bystander responses remain incompletely defined. Here we show that photosentizer activation in a single cell triggers apoptosis in bystander cancer cells, which are electrically coupled by gap junction channels and support ...