A clinical study to measure anti‐erosion properties of a stabilized stannous fluoride dentifrice relative to a sodium fluoride/triclosan dentifrice

作者：NX West, Joon Seong, Nicola Hellin, Holly Eynon, ML Barker, Tao He · 发表于：International Journal of Dental Hygiene · 年份：2015 · DOI：10.1111/idh.12159 · 被引用次数：30 · 研究领域：Dental Erosion and Treatment、Dental materials and restorations、Dental Health and Care Utilization

Abstract Objective To compare the enamel protection efficacy of a stabilized stannous fluoride (SnF2) dentifrice to a sodium fluoride (NaF)/triclosan dentifrice following acidic erosive challenge. Methods In thisin situ, randomized, controlled, double‐blind, two‐treatment, four‐period crossover clinical trial, subjects wore an appliance fitted with human enamel samples 6 h day−1during each 15‐day treatment period. Twice each treatment day they swished with their assigned dentifrice slurry: 0.454% SnF2/0.077% NaF or 0.32% NaF/0.3% triclosan. After each treatment and two other times daily, subjects swished with 250 ml of orange juice over a 10‐min period (acidic erosive challenge). Enamel samples were measured for tooth surface loss using contact profilometry at baseline and days 10 and 15. Results Thirty‐six subjects (mean age 44.8 years, range 23–65 years) were randomized to treatment; 33 subjects completed the final study visit. There were no statistically significant baseline differences (P > 0.44) in the specimen surfaces of the two dentifrice treatment groups via profilometry. At day 10, the SnF2dentifrice provided a statistically significant (P < 0.0001) reduction in enamel loss by 67% versus the NaF/triclosan dentifrice with estimated medians of 1.22 and 3.68 μm, respectively. At day 15, the SnF2dentifrice again provided a significantly greater benefit (P < 0.0001) against tooth surface loss versus the NaF/triclosan dentifrice, with 68% less erosion, and estimated media...