Ku80 cooperates with CBP to promote COX-2 expression and tumor growth

作者：Yao Xiao, Jingshu Wang, Qin Yu, Xuan Yang, Yunlu Jia, Wenxian Hu, Wendan Yu, Meng Dai, Zhenglin Li, Canhui Yi, Shilei Zhao, Mei Li, Sha Du, Wei Cheng, Xiangsheng Xiao, Yi‐Ming Chen, Taihua Wu, Songshu Meng, Yuhui Yuan, Quentin Liu, Wenlin Huang, Wei Guo, Shusen Wang, Wuguo Deng · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.3508 · 被引用次数：54 · 研究领域：Inflammatory mediators and NSAID effects、Estrogen and related hormone effects、Tannin, Tannase and Anticancer Activities

// Yao Xiao 1,* , Jingshu Wang 2,* , Yu Qin 1 , Yang Xuan 1 , Yunlu Jia 3 , Wenxian Hu 3 , Wendan Yu 1 , Meng Dai 1 , Zhenglin Li 1 , Canhui Yi 1 , Shilei Zhao 1 , Mei Li 1 , Sha Du 1 , Wei Cheng 1 , Xiangsheng Xiao 2 , Yiming Chen 1 , Taihua Wu 1 , Songshu Meng 1 , Yuhui Yuan 1 , Quentin Liu 1,2 , Wenlin Huang 2,4 , Wei Guo 1 , Shusen Wang 2 and Wuguo Deng 1,2,4 1 Institute of Cancer Stem Cell & First Affiliated Hospital, Dalian Medical University, Dalian, China 2 Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China 3 Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China 4 State Key Laboratory of Targeted Drug for Tumors of Guangdong Province, Guangzhou Double Bioproduct Inc., Guangzhou, China * These authors contributed equally to this article Correspondence to: Shusen Wang, email: // Wei Guo, email: // Wuguo Deng, email: // Keywords : Ku80, CBP, COX-2, lung cancer Received : December 30, 2014 Accepted : February 04, 2015 Published : March 08, 2015 Abstract Cyclooxygenase-2 (COX-2) plays an important role in lung cancer development and progression. Using streptavidin-agarose pulldown and proteomics assay, we identified and validated Ku80, a dimer of Ku participating in the repair of broken DNA double strands, as a new binding protein of the COX-2 gene promoter. Overexpression of Ku80 up-regulated COX-2 promoter activation and ...