Organogenesis of peripheral lymphoid organs

作者：Shin‐Ichi Nishikawa, Kenya Honda, Paulo Rufino Paulino Vieira, Hisahiro Yoshida · 发表于：Immunological Reviews · 年份：2003 · DOI：10.1034/j.1600-065x.2003.00063.x · 被引用次数：112 · 研究领域：Lymphatic System and Diseases、Cancer Cells and Metastasis、Oral Health Pathology and Treatment

The discovery that lymphotoxin alpha (LTalpha) knockout mice lack peripheral lymphoid tissues reformed the study of organogenesis of peripheral lymphoid tissues from a research field that was solely descriptive and dependent on histological methods to one requiring all modern technologies. The concepts of inducer cells for organogenesis of peripheral lymphoid tissues as a separate hematopoietic lineage and of mesenchymal organizer cells have been established through this progress. These discoveries led to the comprehension of the basic framework of the events during organogenesis of peripheral lymphoid tissues. However, many important questions remain unanswered. This review discusses those questions which have arisen from our studies on the organogenesis of Peyer's patches.