Interleukin 2 deficiency is a common feature of autoimmune mice.

作者：Michael J. Dauphinée, Sophie Kipper, David Wofsy, Norman Talal · 发表于：The Journal of Immunology · 年份：1981 · DOI：10.4049/jimmunol.127.6.2483 · 被引用次数：198 · 研究领域：Systemic Lupus Erythematosus Research、Immune Cell Function and Interaction、Diabetes and associated disorders

IL 2 production was studied in autoimmune mice to assess the role of this lymphokine in the pathogenesis of murine lupus. Spleen and lymph node cells from autoimmune-susceptible mice show an age-dependent loss in the ability to produce functional IL 2. This defect correlates with disease expression and is most severe in MLR/Mp-Ipr/Ipr mice. MLR/Mp-Ipr/Ipr thymocytes gradually lose responsiveness to IL 2 with age. These results suggest that the immunoregulatory abnormalities of autoimmune mice may be due in part to IL 2 deficiency.