Suppression of TNF-α-Induced Apoptosis by NF-κB

作者：Daniel J. Van Antwerp, Séamus J. Martin, Tal Kafri, Douglas R. Green, Inder M. Verma · 发表于：Science · 年份：1996 · DOI：10.1126/science.274.5288.787 · 被引用次数：2619 · 研究领域：NF-κB Signaling Pathways、Immune Response and Inflammation、interferon and immune responses

Tumor necrosis factor alpha (TNF-alpha) signaling gives rise to a number of events, including activation of transcription factor NF-kappaB and programmed cell death (apoptosis). Previous studies of TNF-alpha signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-alpha-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IkappaBalpha (IkappaBalphaM). These findings suggest that a negative feedback mechanism results from TNF-alpha signaling in which NF-kappaB activation suppresses the signals for cell death.