Tissue-type-plasminogen-activator-associated fibrinolysis in orthotopic liver transplantation.

作者：Robert J. Porte, F A Bontempo, E A Knot, Jessica H. Lewis, Yiting Kang, Thomas E. Starzl · 发表于：PubMed · 年份：1989 · 被引用次数：32 · 研究领域：Organ Transplantation Techniques and Outcomes、Transplantation: Methods and Outcomes、Organ and Tissue Transplantation Research

Orthotopic liver transplantation is frequently associated with hemostatic disorders and a bleeding diathesis.1,2 Accelerated fibrinolysis has been recognized as an important component of the hemostatic defect.1,2 The origin of this fibrinolytic activity, however, is still unclear. We investigated the role of tissue-type plasminogen activator (tPA), a potent activator of the fibrinolytic system, in the origin of increased fibrinolytic activity during orthotopic liver transplantation.