Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II.

作者：Daulat R.P. Tulsiani, Thomas Munson Harris, Oscar Touster · 发表于：Journal of Biological Chemistry · 年份：1982 · DOI：10.1016/s0021-9258(18)34274-1 · 被引用次数：466 · 研究领域：Carbohydrate Chemistry and Synthesis、Diet, Metabolism, and Disease、Glycosylation and Glycoproteins Research

In glycoprotein biosynthesis, rat liver Golgi mannosidases IA and IB are a-1,2-specific and convert Mans oligosaccharides to the corresponding Mans species, whereas mannosidase I1 cleaves a-1,3-and a-1,g-man-nosy1 residues from GlcNAcMan5 in completing the mannosyl trimming process (Tulsiani, D.