Protein Sequences Encoded by the relA and the spoT Genes of Escherichia coli Are Interrelated

作者：Shula Metzger, Edoardo Sarubbi, Gad Glaser, Michael Cashel · 发表于：Journal of Biological Chemistry · 年份：1989 · DOI：10.1016/s0021-9258(18)60500-9 · 被引用次数：64 · 研究领域：Bacterial Genetics and Biotechnology、RNA and protein synthesis mechanisms、Protein Structure and Dynamics

relA and spoT are designations for two unlinked Escherichia coli genes whose products function in the synthesis and degradation of guanosine 3',5'-bispyrophosphate during the stringent regulatory response to amino acid deprivation. The RelA protein catalyzes an ATP:GTP 3'-pyrophosphoryl group transfer reaction, and the SpoT protein has a guanosine 3',5'-bispyrophosphate 3'-pyrophosphohydrolyase activity. Both genes have been sequenced recently; the relA gene produces an 84-kDa protein, and the spoT gene is deduced to encode a 79-kDa protein. We report here that the protein sequences of the relA and spoT genes are extensively interrelated.