The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family

作者：David Camerini, Gerd Walz, Wil A. M. Loenen, Jannie Borst, Brian Seed · 发表于：The Journal of Immunology · 年份：1991 · DOI：10.4049/jimmunol.147.9.3165 · 被引用次数：244 · 研究领域：Cancer Immunotherapy and Biomarkers、Immune Cell Function and Interaction、Peptidase Inhibition and Analysis

CD27 is a dimeric membrane glycoprotein found on the surface of most human T lymphocytes. Activation of T cells by engagement of the Ag receptor increases CD27 surface expression, and anti-CD27 antibodies augment Ag receptor-mediated T cell proliferation. In this study a cDNA-encoding CD27 was isolated by expression and immunoselection in COS cells. The predicted polypeptide was found to belong to a recently characterized family of cysteine-rich receptors whose known ligands include nerve growth factor and TNF-alpha and -beta. Structural similarities suggest that CD27 belongs to a lymphocyte-specific subgroup of the family, comprised of the B cell Ag CD40, the rat T cell subset Ag OX40, and the mouse T cell activation Ag 4-1BB. Recent studies suggest some of these molecules may play a role in the survival of activated cells.