Two populations of Ia-like molecules on a human B cell line.

作者：L A Lampson, Ronald Levy · 发表于：The Journal of Immunology · 年份：1980 · DOI：10.4049/jimmunol.125.1.293 · 被引用次数：1103 · 研究领域：Immunodeficiency and Autoimmune Disorders、Monoclonal and Polyclonal Antibodies Research、T-cell and B-cell Immunology

Evidence is presented for two populations of Ia-like molecules on the human B cell line Raji. Two monoclonal antibodies, L203 and L227, are described. Both recognize nonpolymorphic determinants on B cell antigens. Both immunoprecipitate 34,000- and 28,000-dalton material from 125I-labeled extracts of Raji, but L227 precipitates 25,000-dalton material as well. Immunodepletion experiments confirm that the antibodies react with two different populations of molecules.