Cross-resistance to the transplantation of syngeneic Friend, Moloney, and Rauscher virus-induced tumors.

作者：John P. Glynn, J. L. McCoy, A Fefer · 发表于：PubMed · 年份：1968 · 被引用次数：119 · 研究领域：Virus-based gene therapy research、Hepatitis B Virus Studies、T-cell and Retrovirus Studies

Summary Immunofluorescence data are presented which confirm the previously reported cytotoxic antibody studies suggesting that Friend, Moloney, and Rauscher (FMR) virus-induced lymphomas possess similar surface antigens, not shared by Gross lymphomas. It is not known, however, whether the antigenic relationship demonstrable serologically is, or should necessarily be, demonstrable by transplantation studies. To determine if tumors induced by FMR and Gross virus share transplantation antigens, C57BL/6 mice were pretreated with either infectious FMR viruses, FMR lymphomas, or a Gross lymphoma and challenged with syngeneic FMR and Gross lymphomas. Mice pretreated with any one infectious FMR virus or its induced lymphoma became resistant to the transplantation of all FMR lymphomas, but not to the Gross lymphoma. Immunization with the Gross lymphoma failed to induce resistance to the transplantation of the FMR lymphomas, but also failed to induce resistance to itself. The results strongly suggest that FMR lymphomas possess related or identical transplantation antigens.