Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues.

作者：Teruhiro KAYANO, Hirofumi Fukumoto, Roger L. Eddy, Y S Fan, Mary G. Byers, T.B. Shows, Graeme I. Bell · 发表于：Journal of Biological Chemistry · 年份：1988 · DOI：10.1016/s0021-9258(19)37577-5 · 被引用次数：429 · 研究领域：Muscle Physiology and Disorders、Metabolism and Genetic Disorders、Genetics and Neurodevelopmental Disorders

Complementary DNA clones encoding a glucose transporter-like protein have been isolated from a human fetal skeletal muscle cDNA library. The 496-amino acid fetal muscle glucose transporter-like protein has 64.4 and 51.6% identity with the previously described human erythrocyte/HepG2 and liver glucose transporter sequences, respectively. RNA blotting studies indicate that transcripts encoding this glucose transporter-like protein are present in most tissues, although their relative abundance varies. The gene encoding this protein has been localized to human chromosome 12p13.3. The identification and characterization of a third human glucose transporter-related protein suggests that there is a family of proteins having similar sequences and structures which are involved in nutrient transport by mammalian cells.