Clinical implication of long non-coding RNA NEAT1 expression in hepatocellular carcinoma patients.

作者：Sien Guo, Wenjie Chen, Yihuan Luo, Fanghui Ren, Tengfei Zhong, Minhua Rong, Yi‐Wu Dang, Zhen‐Bo Feng, Gang Chen · 发表于：PubMed · 年份：2015 · 被引用次数：127 · 研究领域：Cancer-related molecular mechanisms research、Circular RNAs in diseases、Cancer Mechanisms and Therapy

UNLABELLED: Hepatocellular carcinoma (HCC), a primary malignancy of the liver, is associated with high mortality rate and poor prognosis. Emerging evidence showed that novel biomarkers are required toward a better understanding of the biological mechanisms of HCC. NEAT1 (nuclear paraspeckle assembly transcript 1, also known as MENε/β), a novel long non-coding RNA (lncRNA), serves as a crucial regulator in several cancers. However, the correlation between NEAT1 expression with tumorigenesis and metastasis in HCC tissues remains out of the question so far. In the current study, the aim was to evaluate the potential role of NEAT1 expression in HCC tissues and its relationship with clinicopathological parameters. METHOD: The expression of NEAT1 was detected by qRT-PCR, in 95 cases of adjacent non-cancerous liver and their paired HCC tissues, respectively. The associations of NEAT1 with clinicopathological features and other biological factors were further analyzed. RESULT: Our results revealed that NEAT1 appeared to have higher expression in the HCC tissues, compared with the adjacent non-cancerous liver tissues. High levels of NEAT1 promoted the clinical features of HCC, including the number of tumor nodes, metastasis, clinical TNM stage, the status of portal vein tumor embolus, vaso-invasion and the infiltration of tumor cells. Additionally, high NEAT1 expression levels were significantly associated with the expression level of MDTH, NM23 and MALAT1. CONCLUSION: Our study demon...