Synthesis, Characterization of Dextran Hydrogels and Their in Vitro Release of Gentamycin Sulphate

作者：Rui Guo, Peizhe Chen, Yunfei Mo, Yong Lan, Wei Xue, Yuanming Zhang · 发表于：Journal of Applied Biomaterials & Functional Materials · 年份：2015 · DOI：10.5301/jabfm.5000233 · 被引用次数：5 · 研究领域：Hydrogels: synthesis, properties, applications、biodegradable polymer synthesis and properties、Antimicrobial agents and applications

PURPOSE: This study reports on the synthesis and characterization of biodegradable dextran-allyl isocyanate-ethylamine (Dex-AE)/polyethylene glycol-diacrylate (PEGDA) hydrogels for the controlled release of gentamycin sulphate (GS) and in vitro inhibition of organisms. METHODS: The Dex-AE precursor was prepared through a 2-step chemical modification and characterized by Fourier transform infrared spectroscopy (FTIR). RESULTS: Scanning electron microscopy (SEM) results revealed that an increase in Dex-AE content led to an initial decrease in pore size of the Dex-AE/PEGDA hydrogels, but a further increase in Dex-AE content resulted in a slightly increase of pore size. The swelling data indicated that the swelling ratio depended on the precursor feed ratio. GS was incorporated into the hydrogels through 2 different methods, i.e., immersed and crosslinked. The crosslinked GS-Dex-AE/PEGDA hydorgels exhibited stronger antimicrobial activities against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Finally, the viscoelastic properties of crosslinked GS-Dex-AE/PEGDA hydorgels were investigated.