Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of patterns of recurrence.

作者：Kevin S. Hughes, Richard Simon, Sate Songhorabodi, Martin A. Adson, Ilstrup Dm, Joseph G. Fortner, Barbara J. Maclean, Foster Jh, Jeanette M. Daly, Diane Fitzherbert · 发表于：PubMed · 年份：1986 · 被引用次数：765 · 研究领域：Hepatocellular Carcinoma Treatment and Prognosis、Colorectal Cancer Treatments and Studies、Cholangiocarcinoma and Gallbladder Cancer Studies

The Registry of Hepatic Metastases has collected data on consecutive patients from 24 institutions who have undergone hepatic resection for colorectal carcinoma metastases. Patterns of recurrence were examined in a subgroup of 607 patients who had undergone curative resection of isolated hepatic metastases. Forty-three percent of these patient have had recurrences in the liver and 31% have had recurrences in the lung (either alone or in combination with other organs). A multivariate analysis showed that patients with positive pathologic margins or bilobar metastases were at an increased risk of having a recurrence in the liver (68% and 64%, respectively). We conclude that: hepatic resection effectively controls hepatic tumor in a substantial number of patients, adjuvant therapy after hepatic resection should be directed at both the lung and liver to significantly increase survival, and patients with positive pathologic margins or bilobar metastases are at an increased risk for hepatic recurrence.