Antigenicity of insulin: diabetes induced by specific antibodies

作者：Peter Joseph Moloney, M Coval · 发表于：Biochemical Journal · 年份：1955 · DOI：10.1042/bj0590179 · 被引用次数：194 · 研究领域：Monoclonal and Polyclonal Antibodies Research、Diabetes and associated disorders、Glycosylation and Glycoproteins Research

Lewis (1937) sensitized guinea pigs with ox or pig insulin.Using the Dale technique, he observed contractions of uterine strips from these animals in response to both ox and pig insulin.There was a more persistent response to the preparation of insulin which had been used to sensitize the animal.Bernstein, Kirsner & Turner (1938) have reported anaphylaxis in guinea pigs sensitized and challenged with various insulin preparations.Wasserman & Mirsky (1942) showed that anaphylaxis could be induced in guinea pigs with insulin of a different species than that used for sensitization.Banting, Franks & Gairns (1938) reported the development of resistance to insulin in a non-diabetic schizophrenic patient following a course of insulin shock treat- ment.Blood serum from this patient, mixed with 12-2