FLUCTUATIONS IN HUMAN SERUM LIPOPROTEINS DURING THE NORMAL MENSTRUAL CYCLE

作者：Murray L. Barclay, RK Barclay, VP Skipski, Olga Terebus-Kekish, C.H. Mueller, E.B. Shah, WL ELKINS · 发表于：Biochemical Journal · 年份：1965 · DOI：10.1042/bj0960205 · 被引用次数：60 · 研究领域：Lipid metabolism and disorders、Birth, Development, and Health、Diabetes, Cardiovascular Risks, and Lipoproteins

1. Lipoproteins were measured in sera from 11 young women having a similar environment and diet. Sera were obtained at weekly intervals over a 12-week period. The values of the lipoproteins during periods in the normal ovulatory cycle were compared to assess their relation to reported hormone concentrations in blood. 2. Only the 4-0s(f) (HDL(2)) (d 1.125 sodium chloride) fraction changed significantly; it increased at ovulation in ten of the 11 subjects and fell as menstruation approached. 3. There was greater variability in most of the low-density rather than the high-density lipoproteins within individuals. The lipoprotein class most characteristic for an individual was the 4-0s(f) or HDL(2) fraction.