The presence of human papillomavirus and Epstein-Barr virus in male Chinese lichen sclerosus patients: a single center study

作者：Qiang Fu, Xiong Zhang, Yumeng Zhang · 发表于：Asian Journal of Andrology · 年份：2015 · DOI：10.4103/1008-682x.160261 · 被引用次数：17 · 研究领域：Genital Health and Disease、Urologic and reproductive health conditions、Urological Disorders and Treatments

This study aimed to investigate the presence of human papillomavirus and Epstein-Barr virus in male lichen sclerosus patients. We extracted DNA from formalin-fixed paraffin-embedded foreskin tissue blocks of 47 male LS patients and 30 healthy men and performed real-time PCR test to detect HPV and EBV. None of the 47 LS patients and 30 healthy men had detectable HPV infection. EBV was detected in 18 LS patients (38.3%) and four healthy men (13.3%), the difference is significant (P < 0.05). Tissue blocks with significant inflammatory reaction tend to have higher EBV load. HPV has no significant relationship with LS. Male LS patients have higher EBV infection rate, but the role of EBV in the pathogenesis of LS needs further investigate.