I. Silman

发表论文 449 篇 · 总被引 26704 次 · h-index 80

代表论文

• Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice. (2020 · Journal of Medicinal Chemistry · 被引 89)
• The multiple biological roles of the cholinesterases. (2020 · Progress in Biophysics and Molecular Biology · 被引 58)
• Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. (2019 · European journal of medicinal chemistry · 被引 50)
• Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase. (2019 · European journal of medicinal chemistry · 被引 44)
• Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model (2019 · Communications Chemistry · 被引 33)
• A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides (2020 · Molecules · 被引 32)