Michael R. Gehring

机构：Pfizer (United States)

发表论文 22 篇 · 总被引 884 次 · h-index 14

代表论文

• Design of enzyme inhibitors using iterative protein crystallographic analysis (1991 · Journal of Medicinal Chemistry · 被引 231)
• Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis (1999 · Structure · 被引 204)
• Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular Chaperone (2009 · Journal of Medicinal Chemistry · 被引 73)
• Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone (2008 · Bioorganic & Medicinal Chemistry Letters · 被引 53)
• Expression of Human Pro-Matrix Metalloproteinase 3 that Lacks the N-terminal 34 Residues in Escherichia coli: Autoactivation and Interaction with Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) (1998 · Biological Chemistry · 被引 51)
• Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-Amino-4-{4-chloro-2-[2-(4-fluoro-1 H -pyrazol-1-yl)ethoxy]-6-methylphenyl}- N -(2,2-difluoropropyl)-5,7-dihydro-6 H -pyrrolo[3,4- d ]pyrimidine-6-carboxamide (2011 · Journal of Medicinal Chemistry · 被引 42)