Scott C. Sutton

机构：Pfizer (United States), The Fertilizer Institute · ORCID：0000-0002-7088-3158

发表论文 44 篇 · 总被引 1527 次 · h-index 20

代表论文

• Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor (2021 · Cancer Cell · 被引 194)
• Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance (2016 · Nature Communications · 被引 163)
• Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate ( R )-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2 H )-one (PF-06821497) (2017 · Journal of Medicinal Chemistry · 被引 129)
• Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer (2021 · Journal of Medicinal Chemistry · 被引 121)
• Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants (2016 · Journal of Medicinal Chemistry · 被引 94)
• Practical Singly and Doubly Electrophilic Aminating Agents: A New, More Sustainable Platform for Carbon–Nitrogen Bond Formation (2017 · Journal of the American Chemical Society · 被引 90)