Yue Wu

机构：Pingdingshan University, Shanghai Jiao Tong University, Shanghai First People's Hospital, Center for High Pressure Science & Technology Advanced Research, Northwest Institute of Nuclear Technology, Tsinghua University · ORCID：0009-0002-9020-6573

发表论文 30 篇 · 总被引 840 次 · h-index 12

代表论文

• PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies (2018 · Cell Research · 被引 281)
• Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy (2021 · Nature Chemical Biology · 被引 164)
• Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs (2019 · ACS Medicinal Chemistry Letters · 被引 85)
• Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum ( Pf NDH2) with Small Molecule To Eliminate Drug-Resistant Malaria (2017 · Journal of Medicinal Chemistry · 被引 77)
• Degradation versusInhibition: Development of Proteolysis-Targeting Chimeras for OvercomingStatin-Induced Compensatory Upregulation of 3‑Hydroxy-3-methylglutarylCoenzyme A Reductase (2020 · Journal of Medicinal Chemistry · 被引 62)
• FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice (2020 · Protein & Cell · 被引 39)