David P. Kay

机构：Vertex Pharmaceuticals (United Kingdom)

发表论文 18 篇 · 总被引 884 次 · h-index 10

代表论文

Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents (2011 · Journal of Medicinal Chemistry · 被引 264)
Synthesis and oral antiallergic activity of carboxylic acids derived from imidazo[2,1-c][1,4]benzoxazines, imidazo[1,2-a]quinolines, imidazo[1,2-a]quinoxalines, imidazo[1,2-a]quinoxalinones, pyrrolo[1,2-a]quinoxalinones, pyrrolo[2,3-a]quinoxalinones, and imidazo[2,1-b]benzothiazoles (1988 · Journal of Medicinal Chemistry · 被引 138)
The discovery of the potent aurora inhibitor MK-0457 (VX-680) (2009 · Bioorganic & Medicinal Chemistry Letters · 被引 101)
Synthesis, Structure−Activity Relationships, and Pharmacokinetic Properties of Dihydroorotate Dehydrogenase Inhibitors: 2-Cyano-3-cyclopropyl-3-hydroxy- N-[3‘-methyl-4‘-(trifluoromethyl)phenyl]propenamide and Related Compounds (1996 · Journal of Medicinal Chemistry · 被引 91)
CH···O and CH···N Hydrogen Bonds in Ligand Design: A Novel Quinazolin-4-ylthiazol-2-ylamine Protein Kinase Inhibitor (2005 · Journal of Medicinal Chemistry · 被引 79)
Discovery and Structure−Activity Relationship of 3-Aminopyrid-2-ones as Potent and Selective Interleukin-2 Inducible T-Cell Kinase (Itk) Inhibitors (2011 · Journal of Medicinal Chemistry · 被引 63)