Marian DiFiglia

机构：Harvard University, Massachusetts General Hospital, Mass General Brigham · ORCID：0000-0003-4155-8177

发表论文 229 篇 · 总被引 29669 次 · h-index 79

代表论文

• Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease (2023 · Molecular Therapy · 被引 62)
• Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis (2021 · Molecular Neurobiology · 被引 54)
• Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models (2022 · Nature Communications · 被引 52)
• Enhancing siRNA efficacy in vivo with extended nucleic acid backbones (2024 · Nature Biotechnology · 被引 49)
• Protein changes in synaptosomes of Huntington's disease knock-in mice are dependent on age and brain region (2020 · Neurobiology of Disease · 被引 36)
• Trappc9 deficiency in mice impairs learning and memory by causing imbalance of dopamine D1 and D2 neurons (2020 · Science Advances · 被引 34)