Lisa M. Kopcho

机构：Bristol-Myers Squibb (Germany), Bristol-Myers Squibb (United States), Bristol-Myers Squibb (Sweden)

发表论文 36 篇 · 总被引 849 次 · h-index 18

代表论文

• Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118) (2005 · Archives of Biochemistry and Biophysics · 被引 72)
• Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor (2012 · BMC Pharmacology · 被引 60)
• Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches (2020 · Journal of Medicinal Chemistry · 被引 49)
• MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity (2022 · Cell Metabolism · 被引 47)
• P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid β Reduction by β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice (2008 · Journal of Pharmacology and Experimental Therapeutics · 被引 41)
• Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1 (2010 · Bioorganic & Medicinal Chemistry Letters · 被引 38)