Karen L. Milkiewicz

机构：Teva Pharmaceuticals (United States)

发表论文 25 篇 · 总被引 1249 次 · h-index 16

代表论文

Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells (2005 · Journal of Medicinal Chemistry · 被引 430)
1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2–p53 interaction: discovery and SAR (2004 · Bioorganic & Medicinal Chemistry Letters · 被引 167)
Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo (2006 · Molecular Cancer Therapeutics · 被引 164)
Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design (2006 · Bioorganic & Medicinal Chemistry Letters · 被引 76)
A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5- a ]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779 (2012 · Journal of Medicinal Chemistry · 被引 63)
7-Fluoroindazoles as Potent and Selective Inhibitors of Factor Xa (2007 · Journal of Medicinal Chemistry · 被引 55)