William Gowen-MacDonald

发表论文 11 篇 · 总被引 499 次 · h-index 5

代表论文

Quantifying Ligand Bias at Seven-Transmembrane Receptors (2011 · Molecular Pharmacology · 被引 402)
TRV0109101, a G Protein-Biased Agonist of the µ-Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration (2017 · Journal of Pharmacology and Experimental Therapeutics · 被引 33)
Biased ligands: pathway validation for novel GPCR therapeutics (2014 · Current Opinion in Pharmacology · 被引 30)
Abstract 983: Preclinical characterization of PRT1419, a potent, selective and orally available inhibitor of MCL1 (2021 · Cancer Research · 被引 17)
Abstract 2915: Preclinical characterization of PRT543, a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5), with broad antitumor activity in in vitro and in vivo models (2020 · Cancer Research · 被引 8)
Abstract P237: PRT2527 is a potent and selective CDK9 inhibitor that demonstrates anti-cancer activity in preclinical models of hematological malignancies and solid tumors with MYC amplification (2021 · Molecular Cancer Therapeutics · 被引 5)