Alexander Chan Chi Huang

机构：Hospital of the University of Pennsylvania, Parker Institute for Cancer Immunotherapy, Institute of Immunology, Individual Differences, University of Pennsylvania · ORCID：0000-0002-0099-0492

发表论文 206 篇 · 总被引 20774 次 · h-index 41

代表论文

• Combined JAK inhibition and PD-1 immunotherapy for non–small cell lung cancer patients (2024 · Science · 被引 231)
• Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells (2024 · Cancer Cell · 被引 112)
• LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity (2024 · Cell · 被引 108)
• Engineered extracellular vesicles with DR5 agonistic scFvs simultaneously target tumor and immunosuppressive stromal cells (2025 · Science Advances · 被引 24)
• Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and roles in disease (2025 · Nature Immunology · 被引 19)
• Neoadjuvant-adjuvant pembrolizumab in clinical stage IIB/C melanoma. (2025 · Journal of Clinical Oncology · 被引 10)