Bin Yang

机构：Lanzhou University Second Hospital, Lanzhou University, Northwest A&F University · ORCID：0000-0002-1499-5569

发表论文 82 篇 · 总被引 2826 次 · h-index 26

代表论文

• Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’ chemical space: Recent progress and future challenges (2019 · Bioorganic & Medicinal Chemistry Letters · 被引 404)
• Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist (2020 · Journal of Medicinal Chemistry · 被引 114)
• Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies (2020 · Journal of Medicinal Chemistry · 被引 107)
• Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase (2020 · Journal of Medicinal Chemistry · 被引 50)
• Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement (2021 · Journal of Medicinal Chemistry · 被引 25)
• Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC (2024 · Communications Biology · 被引 23)