Lu-Lin Jiang

机构：Bay Institute, Discovery Institute

发表论文 20 篇 · 总被引 2136 次 · h-index 14

代表论文

• TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function (2018 · Neuron · 被引 822)
• Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models (2018 · Neuron · 被引 429)
• Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72 (2020 · Nature Neuroscience · 被引 237)
• A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease (2022 · Science Translational Medicine · 被引 140)
• ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity (2017 · Nature Communications · 被引 74)
• Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE (2020 · The Journal of Experimental Medicine · 被引 73)