Josephine Ruth Giles

机构：Parker Institute for Cancer Immunotherapy, Translational Therapeutics (United States), University of Pennsylvania · ORCID：0000-0002-3713-338X

发表论文 96 篇 · 总被引 14107 次 · h-index 39

代表论文

• Combined JAK inhibition and PD-1 immunotherapy for non–small cell lung cancer patients (2024 · Science · 被引 231)
• Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells (2024 · Cancer Cell · 被引 112)
• LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity (2024 · Cell · 被引 108)
• KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection (2025 · Science · 被引 83)
• Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate (2025 · Science Immunology · 被引 45)
• TET2 regulates early and late transitions in exhausted CD8 + T cell differentiation and limits CAR T cell function (2024 · Science Advances · 被引 35)