Christopher R. Trotta

机构：University of Chicago, PTC Therapeutics (United States) · ORCID：0000-0001-5749-0133

发表论文 45 篇 · 总被引 3505 次 · h-index 21

代表论文

• CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration (2014 · Cell · 被引 284)
• Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression (2016 · Proceedings of the National Academy of Sciences · 被引 226)
• Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties (2018 · Molecular Cancer Therapeutics · 被引 87)
• Small molecule splicing modifiers with systemic HTT-lowering activity (2021 · Nature Communications · 被引 86)
• The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines (2020 · Virus Research · 被引 74)
• Autosomal-Recessive Mutations in the tRNA Splicing Endonuclease Subunit TSEN15 Cause Pontocerebellar Hypoplasia and Progressive Microcephaly (2016 · The American Journal of Human Genetics · 被引 59)