Thomas Carpenter

机构：Yale University

发表论文 30 篇 · 总被引 443 次 · h-index 9

代表论文

• Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model (2019 · mAbs · 被引 116)
• Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents (2018 · mAbs · 被引 61)
• Bench‐to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T (2021 · CPT Pharmacometrics & Systems Pharmacology · 被引 51)
• Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N-Acetylgalactosamine–Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans (2021 · Journal of Pharmacology and Experimental Therapeutics · 被引 48)
• Development of a minimal physiologically-based pharmacokinetic/pharmacodynamic model to characterize target cell depletion and cytokine release for T cell-redirecting bispecific agents in humans (2020 · European Journal of Pharmaceutical Sciences · 被引 25)
• Improving care pathways for people living with rare bone diseases (RBDs): outcomes from the first RBD Summit (2023 · Osteoporosis International · 被引 16)