Kusum Gupta

ORCID：0000-0001-5888-4732

发表论文 7 篇 · 总被引 99 次 · h-index 5

代表论文

• The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2′-α-chloro-2′-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors (2017 · Bioorganic & Medicinal Chemistry Letters · 被引 33)
• The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075 (2024 · Journal of Medicinal Chemistry · 被引 28)
• Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C (2020 · Journal of Medicinal Chemistry · 被引 26)
• Pharmacokinetics of IDX184, a liver-targeted oral prodrug of 2′-methylguanosine-5′-monophosphate, in the monkey and formulation optimization for human exposure (2015 · European Journal of Drug Metabolism and Pharmacokinetics · 被引 5)
• P1244 FAVORABLE PRECLINICAL PROFILE OF IDX21437, A NOVEL URIDINE NUCLEOTIDE PRODRUG, FOR USE IN A DIRECT-ACTING ANTIVIRAL (DAA) REGIMEN FOR HCV (2014 · Journal of Hepatology · 被引 5)
• Overcoming Stability Challenges in the Quantification of Tissue Nucleotides: Determination of 2′-C-Methylguanosine Triphosphate Concentration in Mouse Liver (2015 · Biological and Pharmaceutical Bulletin · 被引 2)