Kenneth Gable

机构：Uniformed Services University of the Health Sciences · ORCID：0000-0002-9122-1006

发表论文 50 篇 · 总被引 2597 次 · h-index 27

代表论文

• Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis (2021 · Nature Medicine · 被引 155)
• The ORMDL/Orm–serine palmitoyltransferase (SPT) complex is directly regulated by ceramide: Reconstitution of SPT regulation in isolated membranes (2019 · Journal of Biological Chemistry · 被引 107)
• Structural insights into the regulation of human serine palmitoyltransferase complexes (2021 · Nature Structural & Molecular Biology · 被引 105)
• Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration (2015 · Proceedings of the National Academy of Sciences · 被引 81)
• Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency (2016 · Proceedings of the National Academy of Sciences · 被引 61)
• The ORMs interact with transmembrane domain 1 of Lcb1 and regulate serine palmitoyltransferase oligomerization, activity and localization (2018 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 被引 40)