C. Meacham Harrell

机构：Merck & Co., Inc., Rahway, NJ, USA (United States)

发表论文 40 篇 · 总被引 2185 次 · h-index 22

代表论文

• Discovery of the Dual Orexin Receptor Antagonist [(7 R )-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2 H -1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia (2010 · Journal of Medicinal Chemistry · 被引 379)
• Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist (2011 · Journal of Neurogenetics · 被引 270)
• Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors (2016 · Nature Structural & Molecular Biology · 被引 154)
• Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia (2011 · Neuropharmacology · 被引 127)
• Discovery of [(2R,5R)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin Receptor Antagonist with Potent Sleep‐Promoting Properties (2012 · ChemMedChem · 被引 126)
• Design and Synthesis of Novel α1a Adrenoceptor-Selective Antagonists. 1. Structure−Activity Relationship in Dihydropyrimidinones (1999 · Journal of Medicinal Chemistry · 被引 113)