Sophie Cooke

机构：AstraZeneca (Singapore), Abzena (United Kingdom), AstraZeneca (Switzerland) · ORCID：0000-0001-8169-8735

发表论文 19 篇 · 总被引 350 次 · h-index 7

代表论文

• Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase (2020 · Cell · 被引 152)
• Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy (2022 · Nature Communications · 被引 43)
• RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1 (2022 · Journal of Clinical Investigation · 被引 43)
• Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase (2020 · Cell · 被引 31)
• Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity (2024 · Journal of Medicinal Chemistry · 被引 25)
• Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis (2022 · Scientific Reports · 被引 21)