Penelope A. Kosinski

机构：Agios Pharmaceuticals (United States) · ORCID：0000-0002-4465-0924

发表论文 65 篇 · 总被引 1974 次 · h-index 22

代表论文

• Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells (2019 · Immunity · 被引 416)
• AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency (2017 · Blood · 被引 133)
• Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent α-thalassaemia or β-thalassaemia: an open-label, multicentre, phase 2 study (2022 · The Lancet · 被引 89)
• The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model (2021 · Journal of Clinical Investigation · 被引 88)
• AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes (2020 · Haematologica · 被引 83)
• A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease (2022 · Blood · 被引 77)