Jeanne S. Chang

机构：Pfizer (United States) · ORCID：0000-0002-8043-8621

发表论文 42 篇 · 总被引 1783 次 · h-index 17

代表论文

• Delineating the role of cooperativity in the design of potent PROTACs for BTK (2018 · Proceedings of the National Academy of Sciences · 被引 435)
• Discovery of Clinical Candidate 1-{[(2 S ,3 S ,4 S )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design (2017 · Journal of Medicinal Chemistry · 被引 150)
• Discovery of a Highly Selective Glycogen Synthase Kinase‐3 Inhibitor (PF‐04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging (2016 · Angewandte Chemie International Edition · 被引 96)
• Discovery of SARS-CoV-2 papain-like protease (PL pro ) inhibitors with efficacy in a murine infection model (2024 · Science Advances · 被引 55)
• Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free‐Energy Perturbation (FEP) (2015 · ChemMedChem · 被引 49)
• PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease (2020 · Journal of Medicinal Chemistry · 被引 44)