Ishrut Hussain

机构：University of Lincoln

发表论文 63 篇 · 总被引 4329 次 · h-index 31

代表论文

• Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor protein (2003 · Proceedings of the National Academy of Sciences · 被引 362)
• Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts (2001 · Current Biology · 被引 304)
• Cellular prion protein regulates β-secretase cleavage of the Alzheimer's amyloid precursor protein (2007 · Proceedings of the National Academy of Sciences · 被引 270)
• Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production in vivo (2006 · Journal of Neurochemistry · 被引 201)
• BACE1 Cytoplasmic Domain Interacts with the Copper Chaperone for Superoxide Dismutase-1 and Binds Copper (2005 · Journal of Biological Chemistry · 被引 125)
• Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice (2011 · Biochemical Journal · 被引 121)