Angela V. Toms

发表论文 52 篇 · 总被引 4450 次 · h-index 20

代表论文

• The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP (2008 · Proceedings of the National Academy of Sciences · 被引 2150)
• Molecular basis of USP7 inhibition by selective small-molecule inhibitors (2017 · Nature · 被引 483)
• Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase (2016 · Journal of Medicinal Chemistry · 被引 414)
• Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1 (2013 · Cell Reports · 被引 221)
• Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition (2012 · The Journal of Experimental Medicine · 被引 164)
• Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor (2020 · Journal of Medicinal Chemistry · 被引 151)