Darran P. O’Connor

机构：Royal College of Surgeons in Ireland · ORCID：0000-0002-8835-1547

发表论文 254 篇 · 总被引 4660 次 · h-index 39

代表论文

• E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1 (2024 · Acta Pharmacologica Sinica · 被引 11)
• Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer (2023 · Cellular Oncology · 被引 8)
• DCAF7 recruits USP2 to facilitate hepatocellular carcinoma progression by suppressing clockophagy-induced ferroptosis (2025 · Cell Death and Disease · 被引 7)
• Analysis of cell free DNA to predict outcome to bevacizumab therapy in colorectal cancer patients (2024 · npj Genomic Medicine · 被引 2)
• The immune microenvironment in hormone positive, HER2 negative breast cancer: A focus on tumour infiltrating lymphocytes, spatial phenotypes and tertiary lymphoid structures. (2023 · Journal of Clinical Oncology · 被引 2)
• Spatial analyses implicate high stromal tumour-infiltrating CD8+ lymphocytes as a negative predictive marker for chemotherapy in estrogen receptor-positive breast cancer (2026 · Nature Communications)