Adriana Zupa-Fernandez

发表论文 12 篇 · 总被引 1119 次 · h-index 9

代表论文

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165 (2019 · Journal of Medicinal Chemistry · 被引 381)
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain (2019 · Science Translational Medicine · 被引 292)
Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain (2015 · Journal of Biological Chemistry · 被引 117)
Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2) (2019 · Journal of Medicinal Chemistry · 被引 95)
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2 (2020 · Journal of Medicinal Chemistry · 被引 88)
Identification of Imidazo[1,2- b ]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors (2019 · ACS Medicinal Chemistry Letters · 被引 55)