David C. McGowan

ORCID：0000-0002-3759-6771

发表论文 48 篇 · 总被引 1148 次 · h-index 22

代表论文

• Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350 (2008 · Bioorganic & Medicinal Chemistry Letters · 被引 141)
• Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH) (2020 · PLoS ONE · 被引 75)
• Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity (2006 · Journal of Medicinal Chemistry · 被引 67)
• Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids (2015 · Organic Letters · 被引 64)
• Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity (2006 · Journal of Medicinal Chemistry · 被引 61)
• Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA Polymerase (2009 · Journal of Medicinal Chemistry · 被引 60)