Focco van den Akker

机构：Case Western Reserve University · ORCID：0000-0001-9210-3565

发表论文 178 篇 · 总被引 4776 次 · h-index 37

代表论文

• Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234 (2018 · Journal of Medicinal Chemistry · 被引 152)
• AI is a viable alternative to high throughput screening: a 318-target study (2024 · Scientific Reports · 被引 140)
• Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent (2019 · mBio · 被引 121)
• A Standard Numbering Scheme for Class C β-Lactamases (2019 · Antimicrobial Agents and Chemotherapy · 被引 90)
• Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042) (2021 · Journal of Medicinal Chemistry · 被引 67)
• Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam (2022 · Antimicrobial Agents and Chemotherapy · 被引 66)