Jason G. Kettle

机构：Target (United States), The Francis Crick Institute, Cancer Targeted Technology (United States), AstraZeneca (Singapore) · ORCID：0000-0001-7373-0758

发表论文 158 篇 · 总被引 3547 次 · h-index 31

代表论文

• Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration (2023 · Journal of Medicinal Chemistry · 被引 36)
• Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC (2024 · Communications Biology · 被引 25)
• Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor (2025 · Journal of Medicinal Chemistry · 被引 23)
• Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization (2023 · Journal of Medicinal Chemistry · 被引 15)
• Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1 (2024 · Journal of Medicinal Chemistry · 被引 12)
• Site‐Specific Quadruple‐Functionalised Antibodies (2024 · Angewandte Chemie International Edition · 被引 11)